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[Molecular pathogenesis of adult T-cell leukemia/lymphoma].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024

Koya Junji, Kogure Yasunori, Kataoka Keisuke

Abstract excerpt

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive peripheral T-cell malignancy caused by human T-cell leukemia virus type-1 (HTLV-1) infection. Genetic alterations are thought to contribute to the pathogenesis of ATLL alongside HTLV-1 products such as Tax and HBZ. Several large-scale genetic analyses have delineated the entire landscape of somatic alterations in ATLL, which is characterized by frequent...

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PMID: 39358256
DOI: 10.11406/rinketsu.65.1019

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