Article

SOX9-mediated G1 elongation confers reserve stem cell-associated injury resistance in human intestinal stem cells

2026-08-24

Abstract excerpt

<h4>Background: </h4> & Aims Dynamic cell cycle control is critical for intestinal crypt maintenance and injury responses, yet genetic regulators driving these changes remain poorly defined. As reserve intestinal stem cells (rISCs) are often considered to be slowly-cycling and can resist replication-dependent injury, factors that restrain proliferation may confer cytoprotection. Here, we define SOX9 as a regulator...

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Literature Corpus work: 54d59924-1df6-56eb-b9bc-dcfa16da7c4b
DOI: 10.64898/2026.08.21.745750

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