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Lgr5 + intestinal stem cells are required for organoid survival after genotoxic injury

6 Nov 2024

Abstract excerpt

Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage. Here, we modeled fISC activation in mouse intestinal organoids with doxorubicin (DXR) treatment, a chemotherapeutic known to ablate Lgr5+ aISCs in vivo. Similar fISC gene activation was observed between organoids treated with low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39503201
DOI: 10.1242/dev.202941

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