Article

HypoxamicroRNA-210 protects against hepatic steatosis by inhibiting CIDEC expression

2025-12-20

Abstract excerpt

<h4>Background and Aims:</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global health burden. Although hypoxia is known to contribute to MASLD pathogenesis, the role of hypoxia signaling remains poorly defined. We investigated whether HypoxamicroRNA-210 (miR-210), a key hypoxia-inducible microRNA, regulates hepatic lipid metabolism and MASLD development. <h4>Methods:</h4> Serum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54cb63b6-d00d-58f7-8d2d-50a4d98ab90b
DOI: 10.64898/2025.12.19.695309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HypoxamicroRNA-210 protects against hepatic steatosis by inhibiting CIDEC expressionDOI 10.64898/2025.12.19.695309Read

miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic studySemantic proximity Read

Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.Semantic proximity Read

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticlesSemantic proximity Read

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.Semantic proximity Read

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.Semantic proximity Read

Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210Semantic proximity Read

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis–Dependent Ferroptotic VulnerabilitySemantic proximity Read

Hepatocyte TonEBP promotes metabolic stress-induced hepatic fibroinflammation involving transcriptional activation of ELR⁺ CXC chemokinesSemantic proximity Read

Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and MiceSemantic proximity Read

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cellsSemantic proximity Read

HypoxamiR Regulation and Function in Ischemic Cardiovascular DiseasesSemantic proximity Read

LncRNA MIR210HG promotes phenotype switching of pulmonary arterial smooth muscle cells through autophagy-dependent ferroptosis pathway.Semantic proximity Read