Article

miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic study

2024-10-21

Abstract excerpt

MiR-210 is widely recognized as the quintessential hypoxia-responsive miRNA and thought to fine-tune various facets of cellular homeostasis. We hereby present an integrative appraisal of phenotypic and molecular repercussions of disrupting the corresponding locus in human and mouse cells using multiple genetic strategies. Briefly, MIR210 deletion led to decreased cellular fitness and suboptimal responses to severa...

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Literature Corpus work: df5b1792-85b4-5124-ac27-68657072ba70
DOI: 10.1101/2024.10.18.619004

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