Article

Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and Mice

2023-06-27

Abstract excerpt

The inability to efficiently metabolize homocysteine (Hcy) due to nutritional and genetic deficiencies, leads to hyperhomocysteinemia (HHcy) and endothelial dysfunction, a hallmark of atherosclerosis which underpins cardiovascular disease (CVD). PHF8 is a histone demethylase that demethylates H4K20me1, which affects the mammalian target of rapamycin (mTOR) signaling and autophagy, processes that play important rol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45d24c8e-43fd-58ab-ab59-01666700bf36
DOI: 10.1101/2023.06.27.546759

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and MiceDOI 10.1101/2023.06.27.546759Read

Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of PHF8-targeting miR-22-3p and miR-1229-3p in Human Vascular Endothelial CellsSemantic proximity Read

Homocysteine Metabolites Inhibit Autophagy by Upregulating the Expression of miR-21-5p (LC3, p62, BECN1), miR-155-5p (ATG5, LC3), miR-216-5p (BECN1, ATG5, LC3) and miR-320c-3p (ATG7) in Human Vascular Endothelial CellsSemantic proximity Read

Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular DiseaseSemantic proximity Read

Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine β-Synthase-Deficient MiceSemantic proximity Read

Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of HyperhomocysteinemiaSemantic proximity Read

Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated AtherosclerosisSemantic proximity Read

MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemiaSemantic proximity Read

Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic RewiringSemantic proximity Read

HypoxamicroRNA-210 protects against hepatic steatosis by inhibiting CIDEC expressionSemantic proximity Read

The Link Between Hyperhomocysteinemia and HypomethylationSemantic proximity Read

Notable epigenetic role of hyperhomocysteinemia in atherogenesisSemantic proximity Read

Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degenerationSemantic proximity Read