Article

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis–Dependent Ferroptotic Vulnerability

2025-09-14

Abstract excerpt

Colorectal carcinoma (CRC) remains a major cause of cancer-related mortality, with rising incidence in individuals under 55, highlighting the need for novel therapeutic strategies. Hypoxia-inducible factor 2 alpha (HIF-2α) has been genetically validated as a critical driver of colorectal tumorigenesis, with intestinal epithelium–specific deletion in mice markedly reducing tumor formation. PT2385, a selective small...

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Literature Corpus work: 48b92483-df00-5a63-a5f5-3049405b0ad6
DOI: 10.1101/2025.09.08.674939

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