Article
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Nature communications - 10 Sept 2018
Zhang Cai, Seo Joonbae, Murakami Kazutoshi, Salem Esam S B, Bernhard Elise, Borra Vishnupriya J, Choi Kwangmin, Yuan Celvie L, Chan Calvin C, Chen Xiaoting, Huang Taosheng, Weirauch Matthew T, Divanovic Senad, Qi Nathan R, Thomas Hala Einakat, Mercer Carol A, Siomi Haruhiko, Nakamura Takahisa
Abstract excerpt
RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and disturbs energy metabolism in the pathogenesis of obesity. Ago2 regulates expression of specific...
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