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Article

Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.

Oncotarget - 24 Jan 2017

Merlo Anna, Bernardo-Castiñeira Cristóbal, Sáenz-de-Santa-María Inés, Pitiot Ana S, Balbín Milagros, Astudillo Aurora, Valdés Nuria, Scola Bartolomé, Del Toro Raquel, Méndez-Ferrer Simón, Piruat José I, Suarez Carlos, Chiara María-Dolores

Abstract excerpt

The hypoxia-inducible factor 1α (HIF-1α) and its microRNA target, miR-210, are candidate tumor-drivers of metabolic reprogramming in cancer. Neuroendocrine neoplasms such as paragangliomas (PGLs) are particularly appealing for understanding the cancer metabolic adjustments because of their associations with deregulations of metabolic enzymes, such as succinate dehydrogenase (SDH), and the von Hippel Lindau (VHL)...

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Topics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit
Share to MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paraganglioma

Share to Protein Stability

Share to RNA Interference

Share to Succinate Dehydrogenase

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28036268
DOI: 10.18632/oncotarget.14265
PMCID: PMC5351664

Genes

VHL
SDHD
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.PMID 28036268Read ↗

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