Back to search

Article

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells

2020-06-02

Abstract excerpt

<h4>ABSTRACT</h4> FOXA factors are critical members of the developmental gene regulatory network (GRN) composed of master transcription factors (TF) which regulate murine cell fate and metabolism in the gut and liver. How FOXA dictates human liver cell fate, differentiation, and simultaneously regulate metabolic pathways is poorly understood. Here, we aimed to determine the role of FOXA2 (and FOXA1 which is belie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d779cbfb-b051-55b1-bce7-8c01b6881026
DOI
10.1101/2020.06.01.128108
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cellsDOI 10.1101/2020.06.01.128108
FOXA1 /2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell‐derived hepatic progenitor cellsSemantic proximity
A Human Liver Cell Atlas: Revealing Cell Type Heterogeneity and Adult Liver Progenitors by Single-Cell RNA-sequencingSemantic proximity
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cellsSemantic proximity
Integrating Spatial Transcriptomics and Single-Cell RNA-seq Reveals the Gene Expression Profling of the Human Embryonic LiverSemantic proximity
Synthetic Maturation of Multilineage Human Liver Organoids via Genetically Guided EngineeringSemantic proximity
Mapping human liver development using single-cell transcriptomics to reveal pathways directing stem cell fatesSemantic proximity
Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver OrganoidsSemantic proximity
Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal ErythropoiesisSemantic proximity
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cellsSemantic proximity
Liver developmental microenvironment promotes iHSC generation from human iPSCsSemantic proximity
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalingSemantic proximity
Hypoxic Culture Maintains Self-Renewal and Enhances Embryoid Body Formation of Human Embryonic Stem CellsSemantic proximity
Select a neighboring publication to make it the new centre.