Article

Hepatocyte TonEBP promotes metabolic stress-induced hepatic fibroinflammation involving transcriptional activation of ELR⁺ CXC chemokines

2025-08-19

Abstract excerpt

<title>Abstract</title> Metabolic dysfunction-associated steatohepatitis (MASH), a progressive stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by liver inflammation, fibrosis, and hepatocyte injury. Despite its clinical relevance, the molecular mechanisms linking metabolic stress to hepatic fibroinflammation remain poorly understood. In this study, we identify Tonici...

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Literature Corpus work: a62e6f92-2092-5011-9388-4416bd76fd46
DOI: 10.21203/rs.3.rs-7352787/v1

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