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Article

IRF2 degradation tunes the innate immune response

2025-09-24

Abstract excerpt

<h4>Summary</h4> The transcription factor IRF2 protects against skin inflammation in mice and humans but, paradoxically, promotes pyroptosis by inducing Gsdmd . How IRF2 activates some proinflammatory genes, but suppresses others is unclear. We show that skin inflammation in Irf2 -deficient mice is driven by IRF1 activation of interferon-stimulated genes (ISGs). Chromatin profiling revealed that IRF1 and IRF2 o...

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Identifiers and source

Literature Corpus work
54c243ba-13ec-54ca-88f7-a7dbd9a68707
DOI
10.1101/2025.09.23.678148
Open publication

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IRF2 degradation tunes the innate immune responseDOI 10.1101/2025.09.23.678148
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