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Article

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

25 Aug 2023

Abstract excerpt

Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon regulatory factor 1 (IRF1) plays an essential role as a transcription factor in driving the expression of immune response genes during infection. The striking difference in functional...

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PMID: 37622993
DOI: 10.7554/elife.89951

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