Modulation of Epidermal Transcription Circuits in Psoriasis: New Links between Inflammation and Hyperproliferation

Abstract excerpt

BACKGROUND: Whole-genome expression profiling has been used to characterize molecular-level differences between psoriasis lesions and normal skin. Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin biopsies with RNA derived from multiple cell types. RESULTS: We analyzed gene expression across a large sample of psoriatic (PP) and uninvolved/normal (PN)...

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