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Apolipoprotein E (APOE) and Alzheimer's disease risk in a Ugandan population: A pilot case-control study.

Medicine - 9 May 2025

Lwere Kamada, Muwonge Haruna, Sendagire Hakim, Sajatovic Martha, Gumukiriza-Onoria Joy Louise, Buwembo Denis, Buwembo William, Nassanga Rita, Nakimbugwe Rheem, Nazziwa Aisha, Munabi Ian Guyton, Nakasujja Noeline, Kaddumukasa Mark

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by cognitive decline and progressive functional impairment. The Apolipoprotein E (APOE) gene, particularly its ε2, ε3, and ε4 alleles, plays a crucial role in lipid metabolism, and has been implicated in AD pathogenesis. Although the APOE ε4 status is associated with an increased risk of AD, its impact varies across populations. This...

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Identifiers

PMID: 40355218
DOI: 10.1097/MD.0000000000042407
PMCID: PMC12074064

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APOE

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