Article
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Science (New York, N.Y.) - 27 May 2016
Chu Hiutung, Khosravi Arya, Kusumawardhani Indah P, Kwon Alice H K, Vasconcelos Anilton C, Cunha Larissa D, Mayer Anne E, Shen Yue, Wu Wei-Li, Kambal Amal, Targan Stephan R, Xavier Ramnik J, Ernst Peter B, Green Douglas R, McGovern Dermot P B, Virgin Herbert W, Mazmanian Sarkis K
Abstract excerpt
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs). We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to...
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