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Article

Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases.

BioMed research international - 1 Jan 2013

Marcuzzi Annalisa, Bianco Anna Monica, Girardelli Martina, Tommasini Alberto, Martelossi Stefano, Monasta Lorenzo, Crovella Sergio

Abstract excerpt

Crohn's disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder. Several genetic variations have been associated with an increased risk of developing the disease and most of these are also...

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PMID: 23738324
DOI: 10.1155/2013/297501
PMCID: PMC3662122

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