Article

An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression

2024-07-22

Abstract excerpt

Genome-wide association studies (GWAS) of disease progression are vulnerable to collider bias caused by selection of participants with disease at study entry. This bias introduces spurious associations between disease progression and genetic variants that are truly only associated with disease incidence. Methods of statistical adjustment to reduce this bias have been published, but rely on assumptions regarding th...

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Literature Corpus work: 546c996f-4c5b-5d83-b0ee-523b62c692ff
DOI: 10.1101/2024.07.19.604143

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