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Article

Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression.

PLoS genetics - 1 Feb 2023

Mitchell Ruth E, Hartley April E, Walker Venexia M, Gkatzionis Apostolos, Yarmolinsky James, Bell Joshua A, Chong Amanda H W, Paternoster Lavinia, Tilling Kate, Smith George Davey

Abstract excerpt

Genetic studies of disease progression can be used to identify factors that may influence survival or prognosis, which may differ from factors that influence on disease susceptibility. Studies of disease progression feed directly into therapeutics for disease, whereas studies of incidence inform prevention strategies. However, studies of disease progression are known to be affected by collider (also known as...

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PMID: 36821633
DOI: 10.1371/journal.pgen.1010596
PMCID: PMC9949638

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