Article
Genome-Wide Association Study of CKD Progression.
Journal of the American Society of Nephrology : JASN - 1 Sept 2023
Robinson-Cohen Cassianne, Triozzi Jefferson L, Rowan Bryce, He Jing, Chen Hua C, Zheng Neil S, Wei Wei-Qi, Wilson Otis D, Hellwege Jacklyn N, Tsao Philip S, Gaziano J Michael, Bick Alexander, Matheny Michael E, Chung Cecilia P, Lipworth Loren, Siew Edward D, Ikizler T Alp, Tao Ran, Hung Adriana M
Abstract excerpt
SIGNIFICANCE STATEMENT: Rapid progression of CKD is associated with poor clinical outcomes. Most previous studies looking for genetic factors associated with low eGFR have used cross-sectional data. The authors conducted a meta-analysis of genome-wide association studies of eGFR decline among 116,870 participants with CKD, focusing on longitudinal data. They identified three loci (two of them novel) associated...
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