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Article

Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression

2021-05-11

Abstract excerpt

When quantitative longitudinal traits are risk factors for disease progression and subject to random biological variation, joint model analysis of time-to-event and longitudinal traits can effectively identify direct and/or indirect genetic association of single nucleotide polymorphisms (SNPs) with time-to-event. We present a joint model that integrates: i) a multivariate linear mixed model describing trajectories...

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Literature Corpus work
5cee7b4e-9268-57fa-9799-f3e26bae252b
DOI
10.1101/2021.05.10.21256880
Open publication

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Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progressionDOI 10.1101/2021.05.10.21256880
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