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Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression.

Genetics - 31 Aug 2023

Brossard Myriam, Paterson Andrew D, Espin-Garcia Osvaldo, Craiu Radu V, Bull Shelley B

Abstract excerpt

When quantitative longitudinal traits are risk factors for disease progression and subject to random biological variation, joint model analysis of time-to-event and longitudinal traits can effectively identify direct and/or indirect genetic association of single nucleotide polymorphisms (SNPs) with time-to-event. We present a joint model that integrates: (1) a multivariate linear mixed model describing...

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PMID: 37369448
DOI: 10.1093/genetics/iyad119

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