Article

Comparison of methods for assessing effects of risk factors on disease progression in Mendelian randomization under index event bias

2026-03-02

Abstract excerpt

Mendelian randomization has emerged as a transformative approach for inferring causal relationships between risk factors and disease outcomes. However, applying Mendelian randomization to disease progression – a critical step in validating pharmacological targets – is hampered by index event bias. This form of selection bias occurs because analyses of disease progression are necessarily restricted to individuals w...

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Literature Corpus work: 3ecf46cd-5e26-5321-a6e3-95abf6651b10
DOI: 10.64898/2026.02.26.26347193

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