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Article

Estimating Causal Effects on a Disease Progression Trait Using Bivariate Mendelian Randomisation.

Genetic epidemiology - 1 Jan 2025

Cai Siyang, Dudbridge Frank

Abstract excerpt

Genome-wide association studies (GWAS) have provided large numbers of genetic markers that can be used as instrumental variables in a Mendelian Randomisation (MR) analysis to assess the causal effect of a risk factor on an outcome. An extension of MR analysis, multivariable MR, has been proposed to handle multiple risk factors. However, adjusting or stratifying the outcome on a variable that is associated with it...

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Identifiers

PMID: 39445745
DOI: 10.1002/gepi.22600
PMCID: PMC11656144

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