Article

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

2020-01-31

Abstract excerpt

<h4>Background</h4> Studying genetic associations with prognosis (e.g. survival, disability, subsequent disease events) is problematic due to selection bias - also termed index event bias or collider bias - whereby selection on disease status can induce associations between causes of incidence with prognosis. A current method for adjusting genetic associations for this bias assumes there is no genetic correlation...

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Literature Corpus work: 2c648cd4-d0c0-5066-bb05-3ee533c80940
DOI: 10.1101/2020.01.31.928077

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