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Article

Kidney disease progression and collider bias in GWAS.

Kidney international - 1 Sept 2022

Khan Atlas, Kiryluk Krzysztof

Abstract excerpt

New genome-wide meta-analysis for longitudinal kidney function decline identified several genetic loci related to kidney disease progression. The study illustrated the complexity of modeling longitudinal traits in genome-wide association studies and highlighted the issue of a collider bias that can be introduced when a kidney disease progression phenotype is adjusted for baseline kidney function. Herein, we...

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Identifiers

PMID: 35988936
DOI: 10.1016/j.kint.2022.06.018

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