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Article

Arteriovenous malformation in the adult mouse brain resembling the human disease.

Annals of neurology - 1 Jun 2011

Walker Espen J, Su Hua, Shen Fanxia, Choi Eun-Jung, Oh S Paul, Chen Grant, Lawton Michael T, Kim Helen, Chen Yongmei, Chen Wanqiu, Young William L

Abstract excerpt

OBJECTIVE: Brain arteriovenous malformations (bAVMs) are an important cause of hemorrhagic stroke. The underlying mechanisms are not clear. No animal model for adult bAVM is available for mechanistic exploration. Patients with hereditary hemorrhagic telangiectasia type 2 (HHT2) with activin receptor-like kinase 1 (ALK1; ACVRL1) mutations have a higher incidence of bAVM than the general population. We tested the...

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Share to Activin Receptors, Type II
Share to Arteriovenous Malformations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Jagged-1 Protein

Share to Neovascularization, Pathologic

Share to Serrate-Jagged Proteins

Share to Transduction, Genetic

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 21437931
DOI: 10.1002/ana.22348
PMCID: PMC3117949

Genes

ACVRL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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