Article

<i>Alk1</i> mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations

2020-05-21

Abstract excerpt

<h4>Rationale</h4> Mutation in human arteriovenous malformation (AVM) causative genes in a fraction of endothelial cells (ECs) causes AVMs in mice. It is unclear how a small number of mutant ECs can lead to AVM formation. <h4>Objective</h4> To understand how a fraction of mutant ECs causes AVM, we tested the following hypotheses: (1) activin receptor-like kinase 1 ( Alk1 or Acvlr1 ) mutant brain ECs undergo cl...

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Literature Corpus work: 65e2589b-cc7b-51ab-9f53-6ae537ba0534
DOI: 10.1101/2020.05.20.106799

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