Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2023

Zhou Xingyan, Pucel Jenna C, Nomura-Kitabayashi Aya, Chandakkar Pallavi, Guidroz Adella P, Jhangiani Nikita L, Bao Duran, Fan Jia, Arthur Helen M, Ullmer Christoph, Klein Christian, Marambaud Philippe, Meadows Stryder M

Abstract excerpt

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder characterized by arteriovenous malformations and blood vessel enlargements. However, there are no effective drug therapies to combat arteriovenous malformation formation in patients with HHT. Here, we aimed to address whether elevated levels of ANG2 (angiopoietin-2) in the endothelium is a conserved feature in mouse models of the 3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiopoietin-2
Share to Arteriovenous Malformations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Phenotype

Share to Telangiectasia, Hereditary Hemorrhagic

Share to Vascular Anomalies and Treatments

Share to Vascular Malformations and Hemangiomas

Source

Open in PubMed Open full text

Identifiers

PMID: 37288572
DOI: 10.1161/ATVBAHA.123.319385
PMCID: PMC10524982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.PMID 37288572Read ↗

Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformationsSemantic proximity Read ↗

VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read ↗

Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult MouseSemantic proximity Read ↗

Modeling Somatic Second-Hit Mutations in Novel Mouse Models of Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read ↗

Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in MouseSemantic proximity Read ↗

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challengesSemantic proximity Read ↗

Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the diseaseSemantic proximity Read ↗

Arteriovenous malformation in the adult mouse brain resembling the human disease.Semantic proximity Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/ <i>Alk1</i> causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverageSemantic proximity Read ↗

Biology of vascular malformations of the brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.