Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification.

Abstract excerpt

Systems genetics holds the promise to decipher complex traits by interpreting their associated SNPs through gene regulatory networks derived from comprehensive multi-omics data of cell types, tissues, and organs. Here, we propose SpecVar to integrate paired chromatin accessibility and gene expression data into context-specific regulatory network atlas and regulatory categories, conduct heritability enrichment...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation
• Share to Gene Regulatory Networks