Article

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment

2023-10-29

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns. However, the mechanisms underlying DNMT3A recruitment to and function within different chromatin environments remain unclear. Using a combination of biochemical and structural approaches we find that DNMT3A interacts using multiple interfaces with chromatin; directly binding generic nucleosome features...

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Literature Corpus work: df40b1f3-cf7d-59f7-b37e-84972437949a
DOI: 10.1101/2023.10.29.564595

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