Article

A privileged ER compartment for post-translational heteromeric assembly of an ion channel

2025-01-31

Abstract excerpt

Mechanisms underlying heterotypic subunit assembly of ion channels and other oligomeric complexes are poorly understood. In the human heart, heteromeric assembly of two isoforms encoded by the human ether-à-go-go related gene ( hERG ) is essential for the normal function of cardiac I Kr in ventricular repolarization, with loss of hERG1b contributing to arrhythmias associated with long QT-syndrome (LQTS). While...

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Literature Corpus work: b155abb3-03cf-5b55-b4e3-4c4841779ac9
DOI: 10.1101/2025.01.30.635714

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