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An Integrated Multi-Omics Analysis Identifying Immune Subtypes of Pancreatic Cancer

21 Dec 2023

Abstract excerpt

Limited studies have explored novel pancreatic cancer (PC) subtypes or prognostic biomarkers based on the altered activity of relevant signaling pathway gene sets. Here, we employed non-negative matrix factorization (NMF) to identify three immune subtypes of PC based on C7 immunologic signature gene set activity in PC and normal samples. Cluster 1, the immune-inflamed subtype, showed a higher response rate to...

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PMID: 38203311
DOI: 10.3390/ijms25010142

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