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Article

Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.

Cancer research communications - 19 Feb 2024

Gorchs Laia, Fernández-Moro Carlos, Asplund Ebba, Oosthoek Marlies, Solders Martin, Ghorbani Poya, Sparrelid Ernesto, Rangelova Elena, Löhr Matthias J, Kaipe Helen

Abstract excerpt

In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38335302
DOI: 10.1158/2767-9764.CRC-23-0405
PMCID: PMC10875982

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