Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer.

doi:10.3389/fimmu.2026.1894080

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer.

Frontiers in immunology - 1 Jan 2026

Wolf Cody L, Ruiz Roxanne K, Khou Sokchea, Cornelison Robert, Stelow Edward B, Kowalewski Karl M, Lazzara Matthew J, Poissonnier Amanda, Coussens Lisa M, Kelly Kimberly A

Abstract excerpt

Background: Pancreatic adenocarcinoma (PDAC) is an abysmal disease with poor clinical outcomes, largely due to limited life-extending treatments. Notably, PDAC displays a T cell-suppressive tumor microenvironment, and the underlying molecular mechanisms that lead to this phenotype remain poorly understood. Methods: Utilizing the TCGA-PAAD dataset, tumor samples were separated by PLEC expression to evaluate...

Read the complete abstract on PubMed

Topics

Humans
Pancreatic Neoplasms
Animals
T-Lymphocytes, Cytotoxic
Mice
Plectin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Microenvironment

Phenotype

Lymphocytes, Tumor-Infiltrating

Female

Carcinoma, Pancreatic Ductal

Cell Line, Tumor

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 42676425
DOI: 10.3389/fimmu.2026.1894080
PMCID: PMC13526953

Genes

PLEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer.PMID 42676425Read ↗

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancerSemantic proximity Read ↗

Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeSemantic proximity Read ↗

Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencingSemantic proximity Read ↗

Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor MicroenvironmentSemantic proximity Read ↗

Comprehensive Genomic Analysis of the Prognostic and Immunological Characteristics of Tertiary Lymphoid structures and CD8+ T-cells in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Advancing Immunotherapy in Pancreatic Cancer: A Brief Review of Emerging Adoptive Cell TherapiesSemantic proximity Read ↗

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity Read ↗

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-SeqSemantic proximity Read ↗

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDACSemantic proximity Read ↗

Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancerSemantic proximity Read ↗

Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Metaanalysis of transcriptional subtypesSemantic proximity Read ↗

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.