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Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer

16 Dec 2024

Abstract excerpt

Cancer-associated fibroblasts (CAFs) represent a major contributor to tumor growth. Cellular senescence is a state of cell-cycle arrest characterized by a pro-inflammatory phenotype. The potential impact of CAF senescence on tumor progression and the tumor microenvironment (TME) remains to be elucidated. Here, we systematically investigated the relationship between CAF senescence and the TME of pancreatic ductal...

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Share to Epigenetics and DNA Methylation
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PMID: 39834857
DOI: 10.1016/j.isci.2024.111612

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