Article

Akt Drives TGF-β-induced Over-secretion of DKK1 and Impairment of Cystic Fibrosis Airway Epithelium Polarity

2023-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial polarity is fundamental in maintaining barrier integrity and tissue protection. In cystic fibrosis (CF), apicobasal polarity of the airway epithelium is lost, resulting in increased apical fibronectin deposition and enhanced susceptibility to bacterial infections. Here we show that CFTR mutation in primary human airway epithelial cells (HAECs) and CFTR knockdown in a HAEC line promo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 540dfd59-9f72-59d8-b756-9f7726196da4
DOI: 10.1101/2023.05.22.541703

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Akt Drives TGF-β-induced Over-secretion of DKK1 and Impairment of Cystic Fibrosis Airway Epithelium PolarityDOI 10.1101/2023.05.22.541703Read

Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiationSemantic proximity Read

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosisSemantic proximity Read

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine IntestineSemantic proximity Read

Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiologySemantic proximity Read

A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.Semantic proximity Read

Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function in human progenitor-like cells.Semantic proximity Read

Noncanonical Wnt planar cell polarity signaling in lung development and diseaseSemantic proximity Read

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missortingSemantic proximity Read

Proteomic analysis reveals WNT3a, TGFβ, and cAMP-dependent cell type differentiation in gastric antral mucosoidsSemantic proximity Read

Opposing Roles of Akt isoforms in intestinal epithelial integrity, inflammation and cell renewal: therapeutic implications or Inflammatory Bowel Disease.Semantic proximity Read

Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polaritySemantic proximity Read

Characterisation of TGF-β2 signalling and function in a human lens cell lineSemantic proximity Read