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A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.

Cells - 3 Feb 2020

Zuo Haoxiao, Trombetta-Lima Marina, Heijink Irene H, van der Veen Christina H T J, Hesse Laura, Faber Klaas Nico, Poppinga Wilfred J, Maarsingh Harm, Nikolaev Viacheslav O, Schmidt And Martina

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-kinase anchoring proteins (AKAPs) is central to cAMP signaling, functional studies regarding their therapeutic value in the lung EMT process are lacking. The human...

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PMID: 32028718
DOI: 10.3390/cells9020356
PMCID: PMC7072527

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