Article

Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polarity

2025-11-06

Abstract excerpt

<h4>Summary</h4> The Planar Cell Polarity (PCP) complex regulates many diverse phenotypes. While recent literature has elucidated key mechanisms underlying PCP, a mechanistic understanding of how these components function as a system to drive polarity is lacking. Here, we develop a comprehensive multicellular mathematical model centered around key PCP phosphorylation events, directly simulating the protein intera...

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Literature Corpus work: 33dd7499-1e91-5b84-af00-443526c2bef9
DOI: 10.1101/2025.11.05.686808

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