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Article

Noncanonical Wnt planar cell polarity signaling in lung development and disease

25 Feb 2020

Abstract excerpt

The planar cell polarity (PCP) signaling pathway is a potent developmental regulator of directional cell behaviors such as migration, asymmetric division and morphological polarization that are critical for shaping the body axis and the complex three-dimensional architecture of tissues and organs. PCP is considered a noncanonical Wnt pathway due to the involvement of Wnt ligands and Frizzled family receptors in...

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PMID: 32096543
DOI: 10.1042/bst20190597

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