Article

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

2018-09-07

Abstract excerpt

<h4>SUMMARY</h4> Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases. Maintenance of apical polarity in the face of CFTR non-polarized delivery and compromised apical retention of mutant CFTRs lacking PDZ-domain protein (NHERF1) interaction, remains enigmatic. Here we show that basola...

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Literature Corpus work: 47936efc-9683-5cdf-90ff-87f7d73634c5
DOI: 10.1101/411322

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