Article

Proteomic analysis reveals WNT3a, TGFβ, and cAMP-dependent cell type differentiation in gastric antral mucosoids

2026-07-27

Abstract excerpt

<title>Abstract</title> <p> Two-dimensional gastric organoid-derived mucosoids provide a physiologically relevant model for studying epithelial differentiation and function. We demonstrated that withdrawal of WNT3a (WNT) and TGFβ inhibitor promotes differentiation and compartmentalization in human gastric mucosoids without impairing functionality. This results in a phenotype resembling the <italic>in vivo</ital...

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Literature Corpus work: c2af9184-01cd-5ba1-94e8-5f242436c46c
DOI: 10.21203/rs.3.rs-10374273/v1

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