Article

Targeting IRAK4 mitigates osteoarthritis by preserving mitochondrial homeostasis and suppressing MAPK/NF-κB-mediated inflammation

2025-11-21

Abstract excerpt

<title>Abstract</title> <p>Osteoarthritis (OA), a prevalent and debilitating condition driven by progressive cartilage degeneration, represents a significant global health challenge due to the absence of effective disease-modifying therapies. Interleukin-1 receptor-associated kinase 4 (IRAK4), a key signaling kinase at the nexus of innate and adaptive immunity, has emerged as a promising therapeutic target for in...

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Literature Corpus work: 0da7aaa7-52e4-53e7-b4c1-24711c68f000
DOI: 10.21203/rs.3.rs-7999197/v1

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