Article
Advances in research on M1/M2 macrophage polarization in the pathogenesis and treatment of osteoarthritis
2025-02-20
Abstract excerpt
Osteoarthritis (OA) is a chronic inflammatory joint disease associated with aging, trauma, obesity and other pathogenic factors. It is a leading cause of pain and disability worldwide. Macrophages, the most abundant immune cells in the synovium, display significant plasticity and heterogeneity, capable of polarizing into pro-inflammatory M1 or anti-inflammatory M2 types, thus playing a crucial role in the onset an...
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Identifiers and source
- Literature Corpus work
- 209bd32a-19c5-5aa4-99d8-72ebc2b61925
- DOI
- 10.1016/j.heliyon.2025.e42881