Article

Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4

2025-03-13

Abstract excerpt

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expressions and pyroptosis via NLRP3 inflammasome in human and mouse macrophages. DKK1 employed TLR4 to initiate NFκB signaling cascade...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b47d0474-4c1f-5638-b63a-90ee6a8f8b9f
DOI: 10.1101/2025.03.11.642660

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4DOI 10.1101/2025.03.11.642660Read

Dickkopf1 fuels inflammatory cytokine responsesSemantic proximity Read

Pyroptosis, inflammasome, and gasdermins in tumor immunitySemantic proximity Read

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseasesSemantic proximity Read

Notch1 Signaling Contributed To TLR4-Triggered NF-kB Activation In MacrophagesSemantic proximity Read

NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigmaSemantic proximity Read

The Dual Role of Toll-like Receptor10Semantic proximity Read

An update on the regulatory mechanisms of NLRP3 inflammasome activationSemantic proximity Read

Toward targeting inflammasomes: insights into their regulation and activationSemantic proximity Read

The NLRP1 Inflammasome in Human Skin and BeyondSemantic proximity Read

NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and CancersSemantic proximity Read

TRIMs: Generalists Regulating the NLRP3 Inflammasome Signaling PathwaySemantic proximity Read

The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophagesSemantic proximity Read