Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling

23 Jun 2021

Abstract excerpt

Abstract Expression and activity of serum- and glucocorticoid-inducible kinase 1 (SGK1) are associated with many metabolic and inflammatory diseases. In this study, we report that SGK1 promotes alternative macrophage polarization and restrains inflammation in the infectious milieu of the gingiva. Inhibition of SGK1 expression or activity enhances characteristics of classically activated (M1) macrophages by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Hormonal Regulation and Hypertension
Share to IL-33, ST2, and ILC Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34162726
DOI: 10.4049/jimmunol.2001455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 SignalingPMID 34162726Read ↗

Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemiaSemantic proximity Read ↗

Gli1+ Inflamm-Stem Cells Engage Extracellular Vesicles to Prime Aberrant Neutrophils for Exacerbating Periodontal ImmunopathologySemantic proximity Read ↗

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors.Semantic proximity Read ↗

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host DiseaseSemantic proximity Read ↗

Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis.Semantic proximity Read ↗

ALPK1 regulates Synovitis in the Temporomandibular Joint via Promoting Nuclear PKM2-Mediated M1 Macrophage PolarizationSemantic proximity Read ↗

IL-37 blocks gouty inflammation by shaping macrophages into a non-inflammatory phagocytic phenotype.Semantic proximity Read ↗

cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway.Semantic proximity Read ↗

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.Semantic proximity Read ↗

Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulationSemantic proximity Read ↗

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB Pathways.Semantic proximity Read ↗

HDAC6-Mediated FoxO1 Acetylation And Phosphorylation Control Periodontal Inflammatory ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.