Article

Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy

2024-03-19

Abstract excerpt

Cancer is a significant global health issue, with treatment challenges arising from intratumor heterogeneity. This heterogeneity stems mainly from somatic evolution, causing genetic diversity within the tumor, and phenotypic plasticity of tumor cells leading to reversible phenotypic changes. However, the interplay of both factors has not been rigorously investigated. Here, we examine the complex relationship betwe...

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Literature Corpus work: 5404bb35-60c1-5cde-b084-7c27e1a581f7
DOI: 10.1101/2024.03.18.585460

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