Transition Therapy: Tackling the Ecology of Tumor Phenotypic Plasticity.

Abstract excerpt

Phenotypic switching in cancer cells has been found to be present across tumor types. Recent studies on Glioblastoma report a remarkably common architecture of four well-defined phenotypes coexisting within high levels of intra-tumor genetic heterogeneity. Similar dynamics have been shown to occur in breast cancer and melanoma and are likely to be found across cancer types. Given the adaptive potential of...

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• Adaptation, Physiological
• Antineoplastic Agents
• Mathematical Concepts
• Melanoma
• Models, Biological