Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.

Abstract excerpt

Cancer is a clonal disease, i.e., all tumor cells within a malignant lesion trace their lineage back to a precursor somatic cell that acquired oncogenic mutations during development and aging. And yet, those tumor cells tend to have genetic and nongenetic variations among themselves-which is denoted as intratumor heterogeneity. Although some of these variations are inconsequential, others tend to contribute to...

Topics

• Animals
• Antineoplastic Agents
• Biomarkers, Tumor
• Cell Plasticity
• Drug Resistance, Neoplasm
• Epigenesis, Genetic
• Genetic Heterogeneity
• Genetic Predisposition to Disease
• Humans
• Mutation
• Neoplasms