Article

Effects of ACE Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype

2024-06-11

Abstract excerpt

An analysis of 1300+ existing ACE mutations revealed that 400+ are damaging and led us to hy-pothesize that carriers of heterozygous loss-of-function (LoF) ACE mutations (which result in low ACE levels) could be at risk for the development of late-onset Alzheimer’s disease (AD) [Danilov, 2024]. Here we quantified blood ACE levels in EDTA-plasma from 41patients with 10 different heterozygous ACE mutations, as well...

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Literature Corpus work: 53f2f6fe-8c32-5ef7-a8f8-bc10dbd7568d
DOI: 10.20944/preprints202406.0599.v1

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